Smim1

The Vel blood group is associated with the SMIM1 gene, which is located in the 1p36 region of chromosome 1. This gene produces small integral membrane protein 1, a single-pass transmembrane protein which carries the Vel antigen but whose structure and function are otherwise poorly understood. SMIM1 was tagged with an opsin-derived N-glycosylation reporter at either the N- or C-terminus and synthesized in vitro using rabbit reticulocyte lysate supplemented with canine pancreatic microsomes as a source of ER membrane. SMIM1 topology was then determined by assessing the N-glycosylation of its N- or C-terminal tags. SMIM1 encodes a 78-amino acid, single transmembrane domain (TMD) containing protein with a predicted TMD at amino acids 47 to 67. The protein was previously predicted to be a type I transmembrane protein (Storry et al., 2013) but has recently been shown to be a type II transmembrane domain protein with amino acids at positions 1 to 47 predicted to constitute the cytoplasmic domain while smim1_mouse

This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries.

SYNE2. CCDC85A. SBNO2. SLC1A3.

It has only been validated for use in IHC with paraffin embedded tissues.

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The Vel antigen is present on red blood cells from all people except rare Vel-negative individuals who can form antibodies to Vel in response to transfusion or pregnancy. These antibodies may cause severe hemolytic reactions in … 2013-06-03 Identifying SMIM1, SMall Integral Membrane protein 1, as the protein encoding the Vel antigen has significantly improved the identification of Vel negative donors. These rare donors are essential for safe blood transfusions.

SMIM1 was tagged with an opsin-derived N-glycosylation reporter at either the N- or C-terminus and synthesized in vitro using rabbit reticulocyte lysate supplemented with canine pancreatic microsomes as a source of ER membrane. SMIM1 topology was then determined by assessing the N-glycosylation of its N- or C-terminal tags.
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Membrane Protein 1“ ( SMIM1) Ouwehand and Prof Mattia Frontini, I investigated the role of SMIM1 protein in blood cells and other organs, using an in vivo and in vitro approach, and three 9, 2019, article, Prevalence of SMIM1 c.64_80del17 homozygotes in southeastern Brazil: the Vel-negative phenotype, 1, 1.

Cytoplasmic expression in several tissues, with additional membranous expression in few tissues. Expression of SMIM1 in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers.
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Cytoplasmic expression in several tissues, with additional membranous expression in few tissues. Cell atlas. Showing subcellular location of SMIM1 (Vel). We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. Summary of SMIM1 expression in human tissue.